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KMID : 0379119880160010033
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Korean Journal of Mycology
1988 Volume.16 No. 1 p.33 ~ p.40
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Original Studies on Antimicrobial Activities and Safety of Natural Naringin in Korea
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Abstract
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To investigate the antimicrobial activities and safety of natural naringin, it was isolated with methanol from peels of Citri fructus, Its hydrolysate, naringenin was obtained by hydrolysis of naringin. In the antimicrobial activities of two components against eleven species of bacteria and eleven species of Fungi were examined by serial dilution method. Its result appeared to the minimal inhibitory concentration(MIC) and the antimicrobial activities of naringin and naringenin were compared. Naringenin showed considerably high order of activities against bacteria. There were no effect aganist Fungi (MIC $gt;l00 ㎍/㎖). In the safety tests of naringin, examined for 50% lethal dose, Blood clinical chemical teats and organ tissue teats. The results showed that 50% lethal does in mice was 1,650 ㎎/㎏. The experiments of administration in rats showed that there were no changes in blood clinical chemical future and organ tissue as control.
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